Dr. Anand K. Tiwari
Dean (Research and Innovation) - ProfessorDepartment
Department of Biotechnology and BioengineeringContact Info
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Email:- View Email
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Phone:- +91 79-61804300
Work Experience
- 17 Years (Including Ph.D.)
- 2001-2008: Ph.D. (Cytogenetics)
- 2008-2010: Post-doctoral Indo UK Major collaborative research project UKIERI, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh.
- 2010-Till Date: Full-time faculty, Institute of Advanced Research, Gandhinagar.
- Ph.D.: 2008, Cytogenetics Specialization (Banaras Hindu University, Varanasi Uttar Pradesh)
- Post Graduation: 2001, M.Sc. Biotechnology (VBS Purvanchal University, Jaunpur, Uttar Pradesh)
- Graduation: 1999, Zoology, Botany, Chemistry (VBS Purvanchal University, Jaunpur, Uttar Pradesh)
- Study of the Miro, mitochondrial outer membrane protein during axonal transport in Alzheimer’s disease model in Drosophila melanogaster.
- Axonal transport is the process occurs in neurons to move the cargos, organelles and synaptic proteins from the cell body to axon for providing important materials for its growth and survival. Axons contain uniformly polarized microtubules which are arranged linearly throughout the axons, with the minus ends in the cell body and the plus ends in the distal tips. This uniform polarity has made neurons particularly useful for studying transport. Two types of axonal transports are Anterograde transport: Cargo transport from the
cell body to axon toward microtubules (MTs) plus end with the help of kinesin motor protein and Retrograde transport: Cargo transport from axon to cell body toward MTs minus end with the help of dynein motor protein. Fast rate, slow rate, long distance and short distance types axonal transports occur in neurons. - Neuronal cells are highly depending on mitochondrial trafficking for their survival. Mitochondrial axonal transport occurs in both the directions, anterograde and retrograde. Miro and Milton proteins help in transport of mitochondria with the help of kinesin and dynein motor proteins. Anterograde transport of mitochondria towards the axon to provide energy for neurons growth, neurotransmission and neuronal survival.
- Retrograde transport toward cell body involves in clearance of damaged mitochondria by mitophagy. Study of axonal transport molecular events is very important to finding the more causes of neurodegenerative. Thus, using Drosophila melanogaster as a model organism we are interested to study the involvement of Miro and mitochondrial dynamic in Alzheimer disease.
- Axonal transport is the process occurs in neurons to move the cargos, organelles and synaptic proteins from the cell body to axon for providing important materials for its growth and survival. Axons contain uniformly polarized microtubules which are arranged linearly throughout the axons, with the minus ends in the cell body and the plus ends in the distal tips. This uniform polarity has made neurons particularly useful for studying transport. Two types of axonal transports are Anterograde transport: Cargo transport from the
- Identification of the neuroprotective potential of selected Indian medicinal plants using Alzheimer’s and Parkinson’s disease model in Drosophila melanogaster.
- Panchal K, & Tiwari AK, (2018). Mitochondrial Dynamics, a Key Executioner in Neurodegenerative Diseases. Mitochondrion. doi: 10.1016/j.mito.2018.11.002 .
- Kumar A, Tiwari AK (2018). Molecular Chaperone Hsp70 and its Constitutively Active Form Hsc70 Play an Indispensable Role During Eye Development of Drosophila melanogaster. Mol Neurobiol. 55:4345-4361. doi: 10.1007/s12035-017-0650-z.
- Panchal K, Tiwari AK. (2017). Drosophila melnaogaster “a potential model organism” for identification of pharmacological properties of plants/plant-derived components. Biomedicine & Pharmacotherapy. 89:1331-1345.
- Panchal K, Kumar A, Tiwari AK (2018). Heat Shock Protein 70 and Molecular Confession during Neurodegeneration. HSP70 Biology & Medicine Springer Nature 14: 3-35.
- Kumar A, Christian P, Panchal K, Guruprasad BR, Tiwari AK. (2017). Supplementation of Spirulina (Arthrospira platensis) Improves Lifespan and Locomotor Activity in Paraquat-Sensitive DJ-1βΔ93 Flies, a Parkinson’s Disease Model in Drosophila melanogaster. Journal of Dietary Supplements. 14:573-588.
Research Grant Completed:
| Sr. No. | Grant Title | Year of Sanction | Funding Agency | Amount (Rs.) | Pl/Co-Pl |
| 1 | Study of the role of molecular chaperon in eye development and rhodopsin trafficking in Drosophila | 2011 | DST, New Delhi | 1645000/- | PL |
| 2 | Study of the role of molecular chaperon & ubiquitin ligases in the progression on Alzheimer’s disease using Drosophilia melanogaster as a model organism | 2010 | GSBTM, Gujarat | 1780640/- | PL |
| 3 | Program Support PI (I was one of the co-PI who received financial support as salary and consumable grant) | 2009 | DBT, New Delhi | 4.3 Crore | Co-Pl |
Research Grant On-going:
| Sl. No | Grant Title | Year | Funding Agency | Amount Sanctioned | PI/Co-PI |
| 1) | Identification of the neuroprotective potential of Spirulina (Arthrospira platensis) using Alzheimer’s disease model in Drosophila melanogaster | 2016 | GUJCOST
Gujarat DST |
2,10000/- (INR) | PI |
| 2) | Study of the role of Appl & Tau gene during mitochondrial axonal transport in Drosophila model of Alzheimer’s disease | 2018 | SERB, New Delhi | 44,42,662/-(INR) | PI |
- UG: BTGEN601, GEN603, DEV 601
- PG: GEN801, DEV801
- Ph.D.: Genetics, Developmental Biology, Microscopy
- https://www.iar.ac.in/faculty2-bio-anand-tiwari.html
- https://www.iiar.res.in/index.php?q=node/185
- https://www.researchgate.net/profile/Dr_Anand_Krishna_Tiwari
