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DrReshu

Dr. Reshu Saxena

Assistant Professor

Contact:-  079-6180-4300
Email:- reshu.saxena@iar.ac.in

Professional & Educational Qualification

  • Postdoctoral Research : 
    • 2018-2019 : Fels Cancer Institute for Personalized Medicine, Temple University, USA
    • 2019-2020 : Lewis Katz School of Medicine, Temple  University, USA
  • Ph.D. : in Life Sciences from JNU, New Delhi, and CSIR-Central Drug Research Institute CDRI, India    2011 – 2016
  • M.Sc. : in Microbiology (minor in Biotechnology) from G.B. Pant University of Agriculture and Technology, Pantnagar, India   2007 – 2009
  • B.Sc. : (Botany, Zoology, Chemistry) from HNB Garhwal University, India              2004-2007

Current Research interest and area working on

Virology, Molecular and Cell Biology, Proteomics, Mitochondrial Biology

  • Postdoctoral research in area of mitochondrial biology with implications in neurovirology and esophageal biology
  • Doctoral research entitled “Modulation of candidate eukaryotic cell protein expression mediated by HIV-1 Nef” focused on understanding how the viral protein Nef sequence heterogeneity is important to host protein regulation and their associated functions

Latest 5 Publications

  1. Saxena R, Saribas S, Jadiya P, Tomar D, Kaminski R, Elrod JW, Safak M. (2020) “Human neurotropic polyomavirus, JC virus, agnoprotein targets mitochondrion and modulates its functions”. 15;553:135-153. doi: 10.1016/j.virol.2020.11.004. Epub Nov 25. PMID: 33278736 [IF: 2.819]
  2. Saxena, R*, Klochkova A*, Murray MG*, Kabir MF, Samad S, Beccari T, Gang J, Patel K, Hamilton, KE, Whelan KA (2019) “Roles for Autophagy in Esophageal Carcinogenesis: Implicationsfor Improving Patient Outcomes”. Cancers, 11 (11) PMID: 31683722 [* Equal contribution] [IF: 5.742]
  3. Saxena R*, Vekariya U K* and Tripathi RK. (2019). “HIV-1 Nef and host proteome analysis: Current perspective”. Life Sciences, 219(322-328) PMID: 30664855 [* Equal contribution] [IF: 3.647]
  4. Kumar P, Sharma T, Kumari S, Saxena R, Tripathi RK et.al . (2019). “HIV-1 Nef physically associate with CAMKIIδ – ASK-1 complex to inhibit p38MAPK signalling and apoptosis in infected cells”. Life Sciences, 224 (263-273) PMID: 30902545 [IF: 3.647]
  5. Saxena R., Vekariya, U.K., Kumar, P., Tripathi, A.K., Ghosh,J.K., & Tripathi,R.K.(2018). “HIV-1 Nef CAWLEAQ motif: a regulator of monocytes invasion through ENO1 modulation”. Mol Cell Biochem. 447(1-2):151-164 PMID:29404888 [IF: 2.057]
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Book chapters:

  1. Kabir, Mohammad & Murray, Mary Grace & Saxena, Reshu & Klochkova, Alena & Cruz, Jasmine & Whelan, Kelly. (2021). “Esophageal Cancers: Leveraging Alterations in Mitochondrial Biology to Improve Patient Outcomes”.(10.1016/B978-0-12-820472-6.00074-8) Chapter In book: Reference Module in Biomedical Sciences
  2. Reshu Saxena, Ritika Bishnoi, Deepak Singla. (2020) “Gene Ontology (GO): Application and Importance in functional annotation of the genomic data”. In book titled “Bioinformatics: Methods and Applications” by Elsevier Publisher (accepted for publication)
  3. Reichenbach Z W, Murray M G, Saxena R, Farkas D, Karassik E G, Klochkova A, Whelan KA (2019). “Clinical and translational advances in esophageal squamous cell carcinoma”. In K. D. Tew, & P. B. Fisher (Eds.), Adv Cancer Res. 144 (95-135) PMID: 31349905 [IF: 5.23]

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Papers in communication:

  1. Reshu Saxena, Murray MG, Alena K, Hall T, M Kabir, Kolmetzky D, Gang J, Moneger AL, Benitez A, DeMarshall M, Klein-Szanto A, Falk G, Elrod J, Muir A, Whelan “IL13-mediated alterations in mitochondrial biology contribute to impaired squamous cell differentiation in Eosinophilic Esophagitis”. 2021. JACI (Journal of Allergy and Clinical Immunology)
  2. Mohommad Kabir, Adam Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Murray, Kelsey Keith, Jozef Madz0, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn Hamilton, Amanda Muir, Marie-Pier Tetreault, and Kelly Whelan. “Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium and age-associated mitochondrial dysfunction”. 2021. Nature Communications (Under Revision)

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Awards and Achievements

  • Best Poster Presentation Award at TriMAD 2019 meeting held at CHOP, UPENN, Philadelphia, USA from 25th to 26th September 2019
  • Awarded Reddy Laboratories junior scientist award in Molecular Biology in ASIOA meeting held (April 10th) in Orlando, USA
  • Travel Fellowship award by DBT, DST (SERB-ITS) and CICS towards attending the International HIV conference – IAS 2015 in Vancouver, Canada
  • Qualified in ICMR-JRF 2010 for JRF (Life Sciences)
  • Qualified in CSIR-NET June 2010 for Lecturership (LS) in Life Sciences
  • Qualified in GATE 2010 in Life Sciences
  • 1st Prize in Science Quiz Competition organized on “National Science Day” in CDRI, 2011
  • 1st Prize in poster competition organized on “ National Science Day” by the Uttranchal Council of Science & Technology (UCOST), 2007
  • 2nd Prize in poster competition organized on “Tuberculosis Day” by State Tuberculosis cell, 2007
  • Reviewer for the journals “Clinical and Translational Immunology” and “Expert opinion on Drug Safety”
  • Abstract Mentor for Abstract Mentor Program in 21st International AIDS Conference ,2016, Durban, South Africa

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Courses Taught at UG/PG

Medical Microbiology, General Microbiology, Introduction to Microbiology and Microbial Diversity

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Important links to follow:

Pubmed:                   https://www.ncbi.nlm.nih.gov/pubmed/?term=reshu+saxena

ORCID Id:                 0000-0001-7252-4688

Researchgate Id:       https://www.researchgate.net/profile/Reshu-Saxena

Google Scholar Id:    https://scholar.google.com/citations?user=llYTqpkAAAAJ&hl=en&oi=ao

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