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DrLaxmidhar

Dr. Laxmidhar Das

Assistant Professor

Contact:-  079-6180-4300
Email:- laxmidhar.das@iar.ac.in

Professional & Educational Qualification

  • Ph.D. : Biochemistry & Molecular Biology, Centre for Advanced Study in Zoology, Institute of Sciences, Banaras Hindu University, Varanasi, India.  2013.
  • M.Sc.: Biotechnology,  Fakir Mohan University, Balasore, Odisha, India  2006.
  • B.Sc. : Fakir Mohan University, Balasore, Odisha, India 2003.
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Postdoctoral Research Experiences:

  1. Postdoctoral Research Associate: 2019 to 2020, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA.
  2. Postdoctoral Fellow: 2018 to 2018, Sungkyunkwan University (SKKU), Suwon, South Korea.
  3. SERB-National Postdoctoral Fellow (NPDF): 2016 to 2018, Department of Life Sciences, National Institute of Technology (NIT), Rourkela, Odisha, India.
  4. Institute Postdoctoral Fellow: 2015 to 2016, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, MP, India.
  5. Postdoctoral Fellow: 2014 to 2015, Department of Physiology, University of Tennessee Health Science Centre, Memphis, Tennessee, USA.
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Current Research interest and area working on

  1. Cancer cell adaptation and metabolism in hypoxic tumour microenvironment.
  2. Molecular mechanism of metastasis and angiogenesis in cancer.
  3. Role of oxidative stress in cancer development and cytokine signalling in cancer.
  4. Antioxidant defence system and redox signalling.
  5. Regulation of epithelial to mesenchymal transition (EMT) in cancer.
  6. Epigenetics of cancer progression.
  7. Cancer prevention and therapy.
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Latest 5 Publication

  1. Rakesh Kumar Sahu, Nitu Saha, Laxmidhar Das, Pushpendra Kumar Sahu, Santhosh Kumar Sariki, and Raghuvir Singh Tomar. (2020). SWI/SNF chromatin remodeling complex contributes to clearance of cytoplasmic protein aggregates and regulates unfolded protein response in Saccharomyces cerevisiae. The FEBS Journal, 287 (14): 3024-3041.
  2. Nibedita Pradhan, Sabnam Parbin, Chahat Kausar, Swayamsiddha Kar, Shradha Mawatwal, Laxmidhar Das, Moonmoon Deb, Dipta Sengupta, Rohan Dhiman, and Samir Kumar Patra (2019). Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering proinflammatory cytokine gene expression in human prostate cancer cells, Food and Chemical Toxicology, 130: 161-173.
  3. Nibedita Pradhan, Sabnam Parbin, Swayamsiddha Kar, Laxmidhar Das, Kirtana R, Dipta Sengupta, Moonmoon Deb, Samir Kumar Patra (2018) Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signalling downstream ERK/Snail axis: Ectopic application of hydrogen peroxide repress CDH1 gene by enhanced DNA methyltransferase activity in human breast cancer, Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(6): 1651-1665.
  4. Sabnam Parbin, Nibedita Pradhan, Laxmidhar Das, Priyanka Saha, Moonmoon Deb, Dipta Sengupta, Samir Kumar Patra (2019) DNA methylation regulates Microtubule-associated tumor suppressor 1 in human non-small cell lung carcinoma, Experimental Cell Research, 374(2): 323-332.
  5. Laxmidhar Das and Manjula Vinayak (2018). Curcumin Modulates Glycolytic Metabolism and Inflammatory Cytokines via Nrf 2 in Dalton’s Lymphoma Ascites Cells In Vivo. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 18(12): 1779- 1791.

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Book chapters:

  1. Nibedita Pradhan, Swayamsiddha Kar, Sabnam Parbin, Dipta Sengupta, Moonmoon Deb, Laxmidhar Das, and Samir Kumar Patra. (2019). Epigenetic dietary interventions for prevention of cancer. Epigenetics of Cancer Prevention (pp. 23-48). Academic Press.

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Courses Taught at UG/PG/Ph.D.

Biochemistry, Human Physiology, Animal Biotechnology and Proteomics

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