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Dr. Dhaval Patel

Assistant Professor

Contact No.:- +91-79-30514152
Email:- dhaval.patel@iar.ac.in; dhaval@iiar.res.in

Professional & Educational Qualification

  • Ph.D.: Biochemistry (Protein Biochemistry and Structural Biology) (The M.S. University of Baroda, 2017)
  • Post Graduation: M.Sc. Bioinformatics (Sardar Patel University, 2009)
  • Graduation: B.Sc. Bioinformatics (Sardar Patel University, 2007)
  • Work Experience: 
    • 2 years Post-Ph.D. research experience and 6 years teaching experience
    • 2017-Till date: Assistant Professor Institute of Advanced Research (IAR, Gandhinagar)
    • 2009-2017: Technical Asst. (DBT sponsored DISC center), Indian Institute of Advanced Research (IIAR, Gandhinagar).

Current Research Interest and Area Working On

  1. Deciphering molecular determinants of protein-ligand binding kinetics through biophysical and structural studies from pathogenic targets.
  2. Recombinant engineering for therapeutic target protein production.
  3. Molecular docking and dynamics simulation assisted virtual screening to identify novel hits against pathogens like Plasmodium, Leishmanial, etc.
  4. Force-field parameterization of metal-complex inorganic therapeutic compounds.
  5. Computational studies of proteins using high-performance computing and Machine learning and AI.

Latest Publications

  1. Manhas A., Patel D., Lone M., and Jha P. (2019) Identification of natural compound inhibitors against PfDXR: A hybrid Structure-based molecular modeling approach with molecular dynamics studies. Journal of Cellular Biochemistry (Accepted).
  2. Patel P, Parmar K, Patel D, Das M. (2018) Inhibition of amyloid fibril formation of lysozyme by ascorbic acid and a probable mechanism of action. Int J Biol Macromol; 114:668-678. (IF: 3.9)
  3. Patel B., Patel D., Chauhan R., Singh D.D. and Pappachan A. (2017) Leishmania donovani XPRT: molecular characterization and evaluation of inhibitors. BBA – Proteins and Proteomics; 2017 Dec 9. pii: S1570-9639(17)30291-1. DOI: 10.1016/j.bbapap.2017.12.002. (IF: 2.6)
  4. Patel D. K., Shah K. R., Pappachan A., Gupta S., Singh D. D. (2016) Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol; 91:338-46. (IF: 3.9).
  5. Shah KR, Patel DK, Pappachan A, Prabha CR, Singh DD. (2015) Characterization of a Kunitz-type serine protease inhibitor from Solanum tuberosum having lectin activity. Int J Biol Macromol; 83:259-69. (IF: 3.9)

PDB Deposition

  • Protein Data Bank (PDB): 5J9G – Structure of Lactobacillus acidophilus glyceraldehyde-3-phosphate dehydrogenase at 2.21 Å resolution.

Awards & Achievements

  1. Awarded travel grant for 23rd Jerusalem School in Life Sciences on “Computational and Structural Biology” on January 10-14, 2016, Givat Ram, The Hebrew University of Jerusalem, Israel by Israel Institute for Advanced Studies (IIAS), Israel.
  2. Travel grant award from EMBO and DST, Govt. of India for attending the conference “Towards novel therapies: Emerging insights from structural & molecular biology”, March 6-8, 2017, EMBO, Groningen, The Netherlands.
  3. Travel grant award from EMBO for EMBO Global Exchange Lecture Course “Structural and biophysical methods for biological macromolecules in solution”, 06-14 th December 2017, Singapore.
  4. Best research group award in IIAR, Gandhinagar (2011).

Additional Information

  1. Life Member, Indian Crystallography Association.
  2. Member of Board of Studies (2014), Faculty of Computer Science, UIAR.
  3. Member of Board of Management (2013)as Research Scholar representative, IIAR.
  4. Member of Board of Management as University student’s representative (2013), IIAR.

Current Collaborations

  1. Dr. Prakash Jha, Associate Professor, Central University of Gujarat, Gandhinagar.
  2. Prof. R. Begum, The M. S. University of Baroda, Vadodara.
  3. Dr. Kirtan Dave, Centre for Interdisciplinary Studies, S. P. University, Gujarat.

Courses Taught at UG / PG / Ph.D.

  1. Introduction to computers (COM101), UIAR (2013-2014)
  2. UG- Basics in Bioinformatics I (BINF 601), Tools & Techniques in Biology UG (TTB 701)
  3. PG- Basics in Bioinformatics II (BINF 801). Biophysics I (BIP 801), Advanced Biophysics (BIP 802)
  4. PhD- Course work module in Bioinformatics.