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Faculty Name
Dr Vijai Singh Group Leader
Mr Nisarg Gohil PhD Student (JRF- University funded) Synthetic Biology Laboratory, IAR, Gandhinagar, India
Ms Gargi Bhattacharjee PhD Student (JRF- University funded) Synthetic Biology Laboratory, IAR, Gandhinagar, India

Our research is focused on expanding the synthetic biology toolbox, CRISPR-Cas9 platform for genome editing and novel biosynthetic pathways for chemicals, biofuels and biomaterials. We seek to apply these advances to address global challenges in drugs, energy supply and the environment. The recent advances in synthetic biology have led to the development of a number of synthetic parts, devices and systems for a wide range of applications in disease diagnostics, disease treatment, and production of biomaterials, biofuels and fine chemicals.

Synthetic biology toolbox plays a key role for exchanging of parts for production, optimization and tuning of chemicals and biofuels. We have a limited number of well characterized genetic parts and a need arises to design and standardize a library of genetic parts such as promoters, ribosome binding sites, transcription factors, protein degradation tags, transcription terminators, and small RNAs-to name a few. Ideally, these parts should be easily exchangeable and used for designing of combinatorial and tuneable pathways. We are developing a genome engineering platform (CRISPR-Cas9 and CRISPRi) for rapid editing of genome towards the development of a fast, robust and high chemicals, fuels and materials producing strains for industrial applications. We are also developing a cell-free expression system for production of toxic protein, incorporation of non-standard amino acids (NSAAs) and testing synthetic pathway or circuits towards use in disease diagnostic, therapeutic and vaccine developments.

Currently, an urgent need arises to develop next generation synthetic circuits and technologies/ methodologies that can solve some of major issues of health, environment and energy. Our research will play a key role in scientific and technology progress at the interface of synthetic biology, bioengineering and healthcare. It will generate a new knowledge and new tools/ assays/ methods facilities towards the world-class research, education and training..

Ongoing Projects

  • Development of synthetic biology toolbox.
  • Development of the CRISPR-Cas9 platform for genome editing and regulation.
  • Development of portable biosensor for heavy metals.
  • Design of novel biosynthetic pathways for chemicals.

Collaborators

  • Prof. Alfonso Jaramillo, School of Life Sciences, University of Warwick, UK.
  • Prof. Pawan K. Dhar, School of Biotechnology, JNU, New Delhi.

Internship students

  • Mr Happy Panchasara, (MSc Biotechnology), Nirma University, Gujarat, India (Sept 2017- June 2018).
  • Ms Shreya Patel (MSc Biotechnology), Nirma University, Gujarat, India (Sept 2017- June 2018).

Past Students

  • Mr Christian Kuete Fofié (PhD student- exchange programme) (C.V. Raman International Fellow, December 2016- June 2017), Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Mr Robert Ramírez García, (MSc Systems and Synthetic Biology), Girona, Spain (May 2017- March 2018). Doing PhD at University of Warwick, UK.
  • Ms Dhruti Bhatt, BSc Biotechnology, Ganpat University, Gujarat, India.
  • Ms Pallar Rachna, BSc Microbiology, Ganpat University, Gujarat, India.
  • Ms Jinny Ran, BSc Biotechnology, IAR, Gandhinagar.
  • Mr Harshil Maniar, BSc Biotechnology, IAR, Gandhinagar.
  • Mr Ashwini Rawal, BSc Biotechnology, IAR, Gandhinagar.
  • Ms Nishi Patel, BSc Biotechnology, IAR, Gandhinagar.
  • Mr Khushal Khambhatti, MSc Biotechnology, IAR, Gandhinagar.
  • Ms Kavisha Vora, MSc Biotechnology, IAR, Gandhinagar.
  • Ms Pooja Singh, MSc Biotechnology, IAR, Gandhinagar.

Additional Information

  • Recognized PhD guide, SBSB, IAR, Gandhinagar.
  • Member secretary : Board of Studies, SBSB, IAR, Gandhinagar.
  • Member: Academic Council, IAR, Gandhinagar.

Note : We encourage applications at doctoral and postdoctoral levels from the energetic researchers and students who have strong background of genetic engineering, microbiology, metabolic engineering and molecular biology if they have own fellowship. Interested candidates should send a current CV to vijai.singh@iar.ac.in

Institute Of Advanced Research
Koba Institutional Area, Gandhinagar, Gujarat - India, 382 007

Phone 079-30514100

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