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Dr. Budhi Sagar Tiwari

Group : Competent students and post-doctoral fellows are welcome

Identifying Chloroplastic components involved in the execution of abiotic stress induced PCD: In animals as well as plants mitochondria play a pivotal role in the regulation of upstream event of PCD induced by abiotic stress like oxidative, heat, salt and chemically induced PCD. Almost all abiotic stresses converge into oxidative condition and they lead to oxidative burst. Mitochondria amplify ROS production through uncoupled e-transport chain leading to the depletion of cellular ATP content, opening of MTP (mitochondrial transition pore) and migration of cytochrome c from mitochondria to cytosol. In Planta, chloroplast represents another source for producing ROS through photochemical reaction of photosynthesis and through chlorophyll biosynthetic pathway. Although frequency and amount of ROS generation by chloroplast is almost equal or even higher than mitochondrial ROS generation, role of chloroplast in abiotic stress induced PCD is poorly known, some scattered and recent studies suggest that chloroplast might play a crucial role in the regulation of PCD. To go in to the deep, we are trying to identify regulatory components of chloroplastic residence that are involved in abiotic stress induced PCD. To decipher these components we are applying the tools of molecular biology and biochemistry.

Along with the above group is interested to decipher nitro-oxidative condition generated within a cell exposed to perturbed environmental cues. It is universally accepted fact that exposure of a plant to most of the abiotic stresses amplifies cellular ROS as well as nitric oxide that are directly involved in execution of cell death. While a coherent or antagonistic effect of both the species cannot be ruled out, most of the reports available so for speak about individual reactive species. We are interested to look at role of both the species together in regulation cell death process.

Extramural Support

Grants applications pending for decision

Dissertation Students (External)

  • Mr. Gyanendra Pratap Dev M.Sc. Biotechnology, VBS Purvanchal University, Jaunpur, UP)
  • Ms. Pooja Gohel*, (M.Sc. Biotechnology, Shree M. & N. Virani Science College, Rajkot)
  • Ms. Mansi Patel* (M.Sc. Biotechnology, Shree M. & N. Virani Science College, Rajkot)

* Both are going to join the lab. w.e.f. 1 st May 2017

Institute Of Advanced Research
Koba Institutional Area, Gandhinagar, Gujarat - India, 382 007

Phone 079-30514100

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