|Ashima Bhardwaj, Ph. D||Group Leader|
|Dr. Kittappa Vinothkumar||supported from ICMR, GSBTM and DBT|
|Mr. Priyabrata Mohanty||supported from ICMR and GSBTM|
|Ms. Neha Rajpara||Supported from ICMR|
Gastroenteritis or infectious diarrhoea, generally caused by viral or bacterial or parasitic infections is responsible for high morbidity and mortality, especially in children. Bacterial gastroenteritis is caused by the agents such as Vibrio spp., Salmonella spp., Shigella spp.,Campylobacter jejuni, Yersinia enterocolitica, enterohemorrhagic Escherichia coli (EHEC) and other diarrheagenic E. coli. Diarrheal diseases caused by multi-drug resistant bacteria such as Vibrio and Shigella spp. are a major health problem in the developing countries with poor hygiene and limited resources. Various mobile genetic elements such as integrons, plasmids and SXT elements are involved in drug resistance. Apart from mobile genetic elements, various inherent mechanisms such as mutations in drug target sites and efflux pumps are also involved in imparting drug resistance.
Inspite of many years since discovery of antibiotics and their use in treating human infections, there is much to learn about these wonder drugs and the arsenal of genes in bacteria that are rapidly making these drugs obsolete. With the increase in resistance to multiple antibiotics used to treat these bugs, it becomes important to understand the genetic factors that spawn resistance in these bugs. The laboratory of Molecular Biology of Diseases is engaged in deciphering the factors that govern multi drug resistance in the clinical isolates of pathogens belonging to Vibrio and Shigella species that cause diarrhea or dysentery.