|Dr. Reena Agrawal Rajput||Group Leader|
|Mr. Naveen CR||Research Scholar|
|Ms. Juhi Lad||Junior Research Fellow|
|Ms. Bijal Mistry||Junior Research Fellow|
|Ms. Dhruvi Shah||Junior Research Fellow|
The immune system responds to infection or injury, by inducing inflammation, with the prime motif of restoring homeostasis. However, deregulated and uncontrolled inflammation may drive disorderly or diseased conditions. The thrust area of the lab is to unravel mysteries of inflammasome activation for exploring intervention possibilities for acute and chronic inflammatory diseases/disorders. We are taking efforts to gain a holistic understanding of inflammasome function and its regulation by integrating molecular and cell biology approaches with in vivo studies.
Current model systems of study include solid tumors, necrotizing enterocolitis and traumatic brain injury. The lab is trying to widen the arena by extensive investigation of the tissue microenvironment that govern the disease outcome. Our current research focuses on mechanisms of signal integration between Inflammasomes and other immune pathways including the role of Myeloid-Derived Suppressor Cells (MDSCs), Tissue associated macrophages (TAMs) and T cells and their possible cross talk. We are exploring small molecule inhibitors or gene silencing for targeting autophagy and manipulating the immune cross talk with major focus on CD40/CD40L and PD1/PD1L.
Further the lab is explicitly exploring the possibility of cellular alchemy. The ongoing research in this direction aims to: reprogramming immune or cancer cells to neurons or to manipulate EMT for better anti-cancer strategy.