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Faculty Name
Dr. Reena Agrawal Rajput Group Leader
Mr. Naveen CR Research Scholar
Ms. Juhi Lad Junior Research Fellow
Ms. Bijal Mistry Junior Research Fellow
Ms. Dhruvi Shah Junior Research Fellow

The immune system responds to infection or injury, by inducing inflammation, with the prime motif of restoring homeostasis. However, deregulated and uncontrolled inflammation may drive disorderly or diseased conditions. The thrust area of the lab is to unravel mysteries of inflammasome activation for exploring intervention possibilities for acute and chronic inflammatory diseases/disorders. We are taking efforts to gain a holistic understanding of inflammasome function and its regulation by integrating molecular and cell biology approaches with in vivo studies.

Current model systems of study include solid tumors, necrotizing enterocolitis and traumatic brain injury. The lab is trying to widen the arena by extensive investigation of the tissue microenvironment that govern the disease outcome. Our current research focuses on mechanisms of signal integration between Inflammasomes and other immune pathways including the role of Myeloid-Derived Suppressor Cells (MDSCs), Tissue associated macrophages (TAMs) and T cells and their possible cross talk. We are exploring small molecule inhibitors or gene silencing for targeting autophagy and manipulating the immune cross talk with major focus on CD40/CD40L and PD1/PD1L.

Further the lab is explicitly exploring the possibility of cellular alchemy. The ongoing research in this direction aims to: reprogramming immune or cancer cells to neurons or to manipulate EMT for better anti-cancer strategy.

Ongoing Projects

  • Deciphering the immunological cross talk of the Myeloid Derived Suppressor Cells (MDSCs) and Tumour-associated macrophages (TAMs) in the model of solid tumor.
  • Targeting the cancer stem cells inhibition as a therapeutic target.
  • To explore inflammasome guided adaptive immunity in the classic models of inflammatory diseases and vaccine reactogenicity.
  • Deciphering the molecular mechanism and developing novel interventions for traumatic injuries.
  • MicroRNA guided cellular reprogramming with focus on generating neurons from immune cells or cancer stem cells.

Funding Sources

  • Department of Biotechnology
  • Department of Science and Technology
  • Gujarat State Biotechnology Mission
  • Indian Council for Medical Research

Collaborators

  • Dr. Manish Nivsarkar, Director, B.V. Patel PERD Centre. Ahmedabad.
  • Dr. Sarat Dalai, Director, Institute of Science, Nirma University, Ahmedabad.
  • Dr. Nawneet Kurrey, Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru
  • Dr. Priti Desai, Scientist, B.V. Patel PERD Centre. Ahmedabad.
  • Dr. Ashish Mehta, Arpan Newborn Care, Ahmedabad.

Dissertation students

External

  • Mr Hyden Simwatachela (M.Sc. Biotechnology, Veer Narmad South Gujarat University)
  • Mr Rajendra Dubey (M.Sc. Biotechnology , MUIS, Ganpat University, Kherva, Gujarat)

Institute Of Advanced Research
Koba Institutional Area, Gandhinagar, Gujarat - India, 382 007

Phone 079-30514100

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