|Dr. Anand K. Tiwari||Group Leader|
|Mr. Ajay Kumar||Research Scholar|
|Ms. Komal Panchal||DST INSPIRE Fellow|
Axonal transport is the process occurs in neurons to move the cargos, organelles and synaptic proteins from the cell body to axon for providing important materials for its growth and survival. Axons contain uniformly polarized microtubules which are arranged linearly throughout the axons, with the minus ends in the cell body and the plus ends in the distal tips. This uniform polarity has made neurons particularly useful for studying transport. Two types of axonal transports are Anterograde transport: Cargo transport from cell body to axon toward microtubules (MTs) plus end with the help of kinesin motor protein and Retrograde transport: Cargo transport from axon to cell body toward MTs minus end with the help of dynein motor protein. Fast rate, slow rate, long distance and short distance types axonal transports occur in neurons.
Neuronal cells are highly depending on mitochondrial trafficking for their survival. Mitochondrial axonal transport occurs in both the directions, anterograde and retrograde. Miro and Milton proteins helps in transport of mitochondria with the help of kinesin and dynein motor proteins. Anterograde transport of mitochondria towards the axon to provide energy for neurons growth, neurotransmission and neuronal survival.
Retrograde transport toward cell body involve in clearance of damaged mitochondria by mitophagy. Study of axonal transport molecular events is very important for find the more causes of neurodegenerative. Thus, using Drosophila melanogaster as a model organism f we are interested to study the involvement of Miro and mitochondrial dynamic in Alzheimer disease.