|Dr. Anju Pappachan||Group Leader|
|Ms. Bhumi Patel||ICMR-SRF|
|Mr. Pinakin Makwana||Research Scholar|
|Mr. Dhaval Patel||Technical Assistant, DISC|
|Mr. Prakash Kulkarni||Trainee, DISC|
Our group is involved in characterizing various metabolic proteins and adhesin proteins of Leishmania donovani- the protozoan parasite causing the deadly visceral Leishmaniasis. Many of these proteins are potential antileishmanial drug targets or vaccine candidates. Structural and functional characterization of these proteins is carried out using protein engineering, X-ray crystallography, biophysical techniques, enzyme functional assays and bioinformatic tools. Insights from these studies will open up avenues for the development of new anti Leishmanials.
We also structurally and functionally characterize proteins involved in Lactobacillus stress response. Lactobacilli, commonly found in the gastrointesinal tract of humans are used as probiotics and in food processing, where they are subjected to various stresses like acidic pH, temperature, oxidative stress etc. However, they are equipped with defense mechanisms to counter such lethal stresses. Studies indicate the importance of underlying stress response molecules. Yet, much is unexplored.
We are also involved in prospecting lectins from plant and microbial sources.
We also develop and maintain various biological databases and bioinformatic tools.