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Faculty Name
Dr. Anju Pappachan Group Leader
Ms. Bhumi Patel ICMR-SRF
Mr. Pinakin Makwana Research Scholar
Mr. Dhaval Patel Technical Assistant, DISC
Mr. Prakash Kulkarni Trainee, DISC

Our group is involved in characterizing various metabolic proteins and adhesin proteins of Leishmania donovani- the protozoan parasite causing the deadly visceral Leishmaniasis. Many of these proteins are potential antileishmanial drug targets or vaccine candidates. Structural and functional characterization of these proteins is carried out using protein engineering, X-ray crystallography, biophysical techniques, enzyme functional assays and bioinformatic tools. Insights from these studies will open up avenues for the development of new anti Leishmanials.

We also structurally and functionally characterize proteins involved in Lactobacillus stress response. Lactobacilli, commonly found in the gastrointesinal tract of humans are used as probiotics and in food processing, where they are subjected to various stresses like acidic pH, temperature, oxidative stress etc. However, they are equipped with defense mechanisms to counter such lethal stresses. Studies indicate the importance of underlying stress response molecules. Yet, much is unexplored.

We are also involved in prospecting lectins from plant and microbial sources.

We also develop and maintain various biological databases and bioinformatic tools.

Ongoing Projects

  • Structural and functional characterization of unique metabolic pathway proteins from Leishmania
  • Structural and functional characterization of stress proteins from Lactobacillus
  • Structural and functional characterization of mucin binding proteins from Lactobacillus acidophilus (Along with Dr. Desh Deepak Singh)
  • Characterization of adhesins from Leishmania (Along with Dr. Desh Deepak Singh).
  • Prospecting of therapeutically relevant lectins from plant source (Along with Dr. Desh Deepak Singh).

Funding sources

  • Department of Biotechnology
  • Department of Science and Technology
  • Indian Council of Medical Research
  • Council of Scientific and Industrial Research

Collaborators

  • Dr. Desh Deepak Singh, Punjab University, Chandigarh
  • Dr. Anupam Nath Jha, Central University, Tezpur
  • Dr. Gayathri Panangat, IISER, Pune

Dissertation students

External

  • Mr Mehul R Kranavat (M.Sc. Biotechnology, MB Patel Science College Campus, Sardar Patel University, Anand)
  • Mr. Mayuraj Singh Chouhan (M.Sc. Biotechnology, MB Patel Science College Campus, Sardar Patel University, Anand)

Institute Of Advanced Research
Koba Institutional Area, Gandhinagar, Gujarat - India, 382 007

Phone 079-30514100

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